Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation
- Authors
- Lu, Y[Lu, Yue]; Yang, JH[Yang, Ju Hye]; Li, X[Li, Xian]; Hwangbo, K[Hwangbo, Kyoung]; Hwang, SL[Hwang, Seung-Lark]; Taketomi, Y[Taketomi, Yoshitaka]; Murakami, M[Murakami, Makoto]; Chang, YC[Chang, Young-Chae]; Kim, CH[Kim, Cheorl-Ho]; Son, JK[Son, Jong-Keun]; Chang, HW[Chang, Hyeun Wook]
- Issue Date
- 1-Dec-2011
- Keywords
- Emodin; IgE; Mast cells; Passive anaphylactic reaction; Syk kinase
- Citation
- BIOCHEMICAL PHARMACOLOGY, v.82, no.11, pp.1700 - 1708
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL PHARMACOLOGY
- Volume
- 82
- Number
- 11
- Start Page
- 1700
- End Page
- 1708
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/68139
- DOI
- 10.1016/j.bcp.2011.08.022
- ISSN
- 0006-2952
- Abstract
- The high-affinity receptor for IgE (Fc epsilon RI)-mediated activation of mast cells plays an important role in allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. Emodin, a naturally occurring anthraquinone derivative in oriental herbal medicines, has several beneficial pharmacologic effects, such as anti-cancer and anti-diabetic activities. However, the anti-allergic effect of emodin has not yet been investigated. To assess the anti-allergic activity of emodin, in vivo passive anaphylaxis animal model and in vitro mouse bone marrow-derived mast cells were used to investigate the mechanism of its action on mast cells. Our results showed that emodin inhibited degranulation, generation of eicosanoids (prostaglandin D(2) and leukotriene C(4)), and secretion of cytokines (TNF-alpha and IL-6) in a dose-dependent manner in IgE/Ag-stimulated mast cells. Biochemical analysis of the Fc epsilon RI-mediated signaling pathways demonstrated that emodin inhibited the phosphorylation of Syk and multiple downstream signaling processes including mobilization of intracellular Ca(2+) and activation of the mitogen-activated protein kinase, phosphatidylinositol 3-kinase, and NF-kappa B pathways. When administered orally, emodin attenuated the mast cell-dependent passive anaphylactic reaction in IgE-sensitized mice. Thus, emodin inhibits mast cell activation and thereby the anaphylactic reaction through suppression of the receptor-proximal Syk-dependent signaling pathways. Therefore, emodin might provide a basis for development of a novel anti-allergic drug. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Science > Department of Biological Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.