Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study
- Authors
- Lee, IH[Lee, In Ho]; Choi, CH[Choi, Chel Hun]; Hong, DG[Hong, Dae Gy]; Song, JY[Song, Jae Yun]; Kim, YJ[Kim, Young Jae]; Kim, KT[Kim, Kyung Tai]; Lee, KW[Lee, Kyu Wan]; Park, IS[Park, Il Soo]; Bae, DS[Bae, Duk Soo]; Kim, TJ[Kim, Tae Jin]
- Issue Date
- Sep-2011
- Keywords
- Clinical study; Granulosa cell tumor; Ovary; Pregnancy; Recurrence
- Citation
- JOURNAL OF GYNECOLOGIC ONCOLOGY, v.22, no.3, pp.188 - 195
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- JOURNAL OF GYNECOLOGIC ONCOLOGY
- Volume
- 22
- Number
- 3
- Start Page
- 188
- End Page
- 195
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/68960
- DOI
- 10.3802/jgo.2011.22.3.188
- ISSN
- 2005-0380
- Abstract
- Objective: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors. Methods: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed. Results: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies. Conclusion: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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