Significance of para-aortic lymph node evaluation in patients with FIGO IIIC1 cervical cancer
- Authors
- Cho, W.K.[Cho, W.K.]; Kim, Y.J.[Kim, Y.J.]; Kim, H.[Kim, H.]; Kim, Y.S.[Kim, Y.S.]; Park, W.[Park, W.]
- Issue Date
- Oct-2020
- Publisher
- Oxford University Press
- Keywords
- lymph node involvement; radiation therapy; uterine cervical neoplasm
- Citation
- Japanese Journal of Clinical Oncology, v.50, no.10, pp.1150 - 1156
- Indexed
- SCIE
SCOPUS
- Journal Title
- Japanese Journal of Clinical Oncology
- Volume
- 50
- Number
- 10
- Start Page
- 1150
- End Page
- 1156
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/6907
- DOI
- 10.1093/jjco/hyaa091
- ISSN
- 0368-2811
- Abstract
- Objective: This study investigated the effect of para-aortic lymph node sampling or dissection in recently revised International Federation of Gynecology and Obstetrics IIIC1p cervical cancer treated with primary surgery and adjuvant radiation therapy with concurrent chemotherapy. Methods: We retrospectively reviewed the records of 343 patients with early-stage cervical cancer and pathologically proven pelvic lymph node metastasis following curative surgery from 2001 to 2014. No patient had imaging evidence of para-aortic lymph node involvement, and all patients received adjuvant concurrent chemotherapy with or without concurrent chemotherapy. We investigated the significance of para-aortic lymph node sampling or dissection on disease-free survival and overall survival. Results: After median follow-up of 58.3 months, 5-year disease-free survival and overall survival in all patients were 69.9 and 80.2%, respectively. Disease-free survival and overall survival did not differ between the para-aortic lymph node dissection group and the No para-aortic lymph node dissection group (P = 0.700 and P = 0.605). However, patients with para-aortic lymph node-positive disease had poorer disease-free survival and overall survival compared with those with para-aortic lymph node-negative disease (P < 0.001 and P < 0.001). Conclusions: This study found no survival benefit of para-aortic lymph node evaluation among patients with International Federation of Gynecology and Obstetrics IIIC1p cervical cancer who were clinically para-aortic lymph node-negative. Although para-aortic lymph node metastasis is a poor prognosticator, the benefit of para-aortic lymph node dissection in terms of survival needs further investigation. © 2020 The Author(s) 2020. Published by Oxford University Press. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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