The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea
- Authors
- Cho, HC[Cho, Hyun Chin]; Kim, YJ[Kim, Yu Jin]; Choi, MS[Choi, Moon Seok]; Lee, JH[Lee, Joon Hyeok]; Koh, KC[Koh, Kwang Cheol]; Yoo, BC[Yoo, Byung Chul]; Paik, SW[Paik, Seung Woon]
- Issue Date
- Jun-2011
- Keywords
- Chronic hepatitis B; Hepatitis A virus vaccination; Hepatitis B virus related liver cirrhosis
- Citation
- GUT AND LIVER, v.5, no.2, pp.217 - 220
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- GUT AND LIVER
- Volume
- 5
- Number
- 2
- Start Page
- 217
- End Page
- 220
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/69754
- DOI
- 10.5009/gnl.2011.5.2.217
- ISSN
- 1976-2283
- Abstract
- Background/Aims: The aim of this study was to evaluate the seroconversion rate of a hepatitis A virus (HAV) vaccination in patients with hepatitis B virus (HBV)-related chronic liver disease (CLD). Methods: Analyses were conducted using clinical records from 94 patients with chronic HBV infection who were seronegative for IgG anti-HAV antibodies between September 2008 and June 2009. Two doses of an HAV vaccine were administered 24 weeks apart. A third vaccine dose was administered only for patients seronegative for anti-HAV antibodies at week 48. Results: The seroconversion rate of anti-HAV following the two-dose vaccination was 86.17%. The seroconversion rate of anti-HAV was not significantly different according to age or status of liver disease. The rate was higher in female than in male patients. A third HAV vaccine dose was administered to 13 patients seronegative for anti-HAV after the two-dose regimen, and 84.62% of these patients showed seroconversion at week 72. Conclusions: HAV vaccination is effective in most Korean patients with HBV-related CLD, and it might be necessary to evaluate three-dose vaccination approach for non-responders to the conventional regimen to maximize the success of an HAV vaccination program. (Gut Liver 2011;5:217-220)
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