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Gombapyrones E and F, New alpha-Pyrone Polyenes Produced by Streptomyces sp. KMC-002open access
- Authors
- Park, HB[Park, Hyun Bong]; Yang, HO[Yang, Hyun Ok]; Lee, KR[Lee, Kang Ro]; Kwon, HC[Kwon, Hak Cheol]
- Issue Date
- May-2011
- Keywords
- α-pyrone; Gombapyrone; Polyene; Streptomyces
- Citation
- MOLECULES, v.16, no.5, pp.3519 - 3529
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULES
- Volume
- 16
- Number
- 5
- Start Page
- 3519
- End Page
- 3529
- ISSN
- 1420-3049
- Abstract
- Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be alpha-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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