Regulation of dopaminergic neuron firing by heterogeneous dopamine autoreceptors in the substantia nigra pars compacta
- Authors
- Jang, JY[Jang, Jin Young]; Jang, M[Jang, Miae]; Kim, SH[Kim, Shin Hye]; Um, KB[Um, Ki Bum]; Kang, YK[Kang, Yun Kyung]; Kim, HJ[Kim, Hyun Jin]; Chung, S[Chung, Sungkwon]; Park, MK[Park, Myoung Kyu]
- Issue Date
- Mar-2011
- Citation
- JOURNAL OF NEUROCHEMISTRY, v.116, no.6, pp.966 - 974
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEUROCHEMISTRY
- Volume
- 116
- Number
- 6
- Start Page
- 966
- End Page
- 974
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/70625
- DOI
- 10.1111/j.1471-4159.2010.07107.x
- ISSN
- 0022-3042
- Abstract
- P>Dopamine (DA) receptors generate many cellular signals and play various roles in locomotion, motivation, hormone production, and drug abuse. According to the location and expression types of the receptors in the brain, DA signals act in either stimulatory or inhibitory manners. Although DA autoreceptors in the substantia nigra pars compacta are known to regulate firing activity, the exact expression patterns and roles of DA autoreceptor types on the firing activity are highly debated. Therefore, we performed individual correlation studies between firing activity and receptor expression patterns using acutely isolated rat substantia nigra pars compacta DA neurons. When we performed single-cell RT-PCR experiments, D(1), D(2)S, D(2)L, D(3), and D(5) receptor mRNA were heterogeneously expressed in the order of D(2)L > D(2)S > D(3) > D(5) > D(1). Stimulation of D(2) receptors with quinpirole suppressed spontaneous firing similarly among all neurons expressing mRNA solely for D(2)S, D(2)L, or D(3) receptors. However, quinpirole most strongly suppressed spontaneous firing in the neurons expressing mRNA for both D(2) and D(3) receptors. These data suggest that D(2)S, D(2)L, and D(3) receptors are able to equally suppress firing activity, but that D(2) and D(3) receptors synergistically suppress firing. This diversity in DA autoreceptors could explain the various actions of DA in the brain.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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