Clinical Characteristics of 327 Asian Patients With Autoimmune Pancreatitis Based on Asian Diagnostic Criteria
- Authors
- Kamisawa, T[Kamisawa, Terumi]; Kim, MH[Kim, Myung-Hwan]; Liao, WC[Liao, Wei-Chih]; Liu, QD[Liu, Quanda]; Balakrishnan, V[Balakrishnan, Vallath]; Okazaki, K[Okazaki, Kazuichi]; Shimosegawa, T[Shimosegawa, Tooru]; Chung, JB[Chung, Jae Bock]; Lee, KT[Lee, Kyu Taek]; Wang, HP[Wang, Hsiu-Po]; Lee, TC[Lee, Tsung-Chun]; Choudhuri, G[Choudhuri, Gourdas]
- Issue Date
- Mar-2011
- Citation
- PANCREAS, v.40, no.2, pp.200 - 205
- Indexed
- SCIE
SCOPUS
- Journal Title
- PANCREAS
- Volume
- 40
- Number
- 2
- Start Page
- 200
- End Page
- 205
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/70705
- DOI
- 10.1097/MPA.0b013e3181fab696
- ISSN
- 0885-3177
- Abstract
- Objectives: To clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) in Asia. Methods: A retrospective, actual situation survey of AIP diagnosed by Asian criteria was conducted in 10 centers of Japan, Korea, Taiwan, China, and India. Results: A total of 327 AIP cases (258 male and 69 female subjects; average age, 60.0 years) were enrolled. Obstructive jaundice was the most frequent initial symptom (46%-74%), followed by weight loss (4%-51%) and abdominal pain (19%-44%). Diffuse swelling of the pancreas was frequent in Japan (64%) and Korea (81%), but segmental swelling of the pancreas was more frequent in Taiwan (70%) and China (72%) (P < 0.01). Serum immunoglobulin G4 levels were elevated in 58%-100% of cases in Japan, Korea, and Taiwan. Pathologically, almost all AIPs in Asia were lymphoplasmacytic sclerosing pancreatitis. Sclerosing cholangitis was the most frequent extrapancreatic lesion (60%-81%). Steroid therapy was a major and effective therapeutic strategy in Japan, Korea, and Taiwan. However, the rate of resection or bypass operation was higher in Taiwan (40%) and China (72%) (P < 0.01). Conclusions: Features of AIP are fundamentally similar in Japan, Korea, Taiwan, and China. Knowledge of emerging AIP should be more widespread in Asia to avoid unnecessary operation.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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