Influenza H1N1 virus-associated pneumonia often resembles rapidly progressive interstitial lung disease seen in collagen vascular diseases and COVID-19 pneumonia; CT-pathologic correlation in 24 patients
- Authors
- Murota, M.[Murota, M.]; Johkoh, T.[Johkoh, T.]; Lee, K.S.[Lee, K.S.]; Franquet, T.[Franquet, T.]; Kondoh, Y.[Kondoh, Y.]; Nishiyama, Y.[Nishiyama, Y.]; Tanaka, T.[Tanaka, T.]; Sumikawa, H.[Sumikawa, H.]; Egashira, R.[Egashira, R.]; Yamaguchi, N.[Yamaguchi, N.]; Fujimoto, K.[Fujimoto, K.]; Fukuoka, J.[Fukuoka, J.]
- Issue Date
- 2020
- Publisher
- Elsevier Ltd
- Keywords
- Computed tomography; COVID-19; Influenza A (H1N1) virus; Myositis and muscle disease; Pneumonia; Rheumatoid arthritis
- Citation
- European Journal of Radiology Open, v.7
- Indexed
- SCOPUS
- Journal Title
- European Journal of Radiology Open
- Volume
- 7
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/7089
- DOI
- 10.1016/j.ejro.2020.100297
- ISSN
- 2352-0477
- Abstract
- Purpose: To describe computed tomography (CT) findings of influenza H1N1 virus-associated pneumonia (IH1N1VAP), and to correlate CT findings to pathological ones. Methods: The study included 24 patients with IH1N1VAP. Two observers independently evaluated the presence, distribution, and extent of CT findings. CT features were divided into either classical form (C-form) or non-classical form (NC-form). C-form included: A.) broncho-bronchiolitis and bronchopneumonia type, whereas NC-forms included: B.) diffuse peribronchovascular type, simulating subacute rheumatoid arthritis-associated (RA) interstitial lung disease (ILD) and C.) lower peripheral and/or peribronchovascular type, resembling dermatomyositis-associated ILD and COVID-19 pneumonia. In 10 cases with IH1N1VAP where lung biopsy was performed, CT and pathology findings were correlated. Results: The most common CT findings were ground-glass opacities (24/24, 100 %) and airspace consolidation (23/24, 96 %). C-form was found in 11 (46 %) patients while NC-form in 13 (54 %). Types A, B, and C were seen in 11(46 %), 4 (17 %), and 9 (38 %) patients, respectively. The lung biopsy revealed organizing pneumonia in all patients and 6 patients (60 %) showed incorporated type organizing pneumonia that was common histological findings of rapidly progressive ILD. Conclusion: In almost half of patients of IH1N1VAP, CT images show NC-form pneumonia pattern resembling either acute or subacute RA or dermatomyositis-associated ILD and COVID-19 pneumonia. © 2020 The Author(s)
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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