Age at diagnosis and the risk of diabetic nephropathy in young patients with type 1 diabetes mellitusAge at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus
- Other Titles
- Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus
- Authors
- Baek, J.H.[Baek, J.H.]; Lee, W.J.[Lee, W.J.]; Lee, B.-W.[Lee, B.-W.]; Kim, S.K.[Kim, S.K.]; Kim, G.[Kim, G.]; Jin, S.-M.[Jin, S.-M.]; Kim, J.H.[Kim, J.H.]
- Issue Date
- Jan-2021
- Publisher
- Korean Diabetes Association
- Keywords
- Diabetes complications; Diabetes mellitus, type 1; Diabetic nephropathies
- Citation
- Diabetes and Metabolism Journal, v.44, no.44, pp.46 - 54
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Diabetes and Metabolism Journal
- Volume
- 44
- Number
- 44
- Start Page
- 46
- End Page
- 54
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/7092
- DOI
- 10.4093/dmj.2019.0134
- ISSN
- 2233-6079
- Abstract
- Background: The aim of this study was to evaluate characteristics and risk of diabetic complications according to age at diagnosis among young adults with type 1 diabetes mellitus (T1DM). Methods: A total of 255 T1DM patients aged less than 40 years were included. Patients were categorized into three groups (<20, 20 to 29, and 30 to 40 years) according to age at diagnosis. Diabetic nephropathy (DN) was defined when spot urine-albumin creatinine ratio was 300 mg/g or more and/or estimated glomerular filtration ratio (eGFR) level was 60 mL/min/1.73 m2 or less. Results: Median age at diagnosis was 25 years and disease duration was 14 years. Individuals diagnosed with T1DM at childhood/adolescent (age <20 years) had lower stimulated C-peptide levels. They received more intensive insulin treatment with higher total daily insulin doses compared to older onset groups. The prevalence of DN was higher in the childhood/adolescent-onset group than in older onset groups (25.3% vs. 15.3% vs. 9.6%, P=0.022). The eGFR was inversely associated with disease duration whilst the degree of decrease was more prominent in the childhood/adolescent-onset group than in the later onset group (aged 30 to 40 years; P<0.001). Childhood/adolescent-onset group was independently associated with the risk of DN compared to the older onset group (aged 30 to 40 years; odds ratio, 3.47; 95% confidence interval, 1.45 to 8.33; P=0.005). Conclusion: In individuals with childhood/adolescent-onset T1DM, the reduction in renal function is more prominent with disease duration. Early age-onset T1DM is an independent risk of DN. © 2020 Korean Diabetes Association
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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