Seroprevalence of anti-HAV among patients with chronic viral liver diseaseopen access
- Authors
- Cho, HC[Cho, Hyun Chin]; Paik, SW[Paik, Seung Woon]; Kim, YJ[Kim, Yu Jin]; Choi, MS[Choi, Moon Seok]; Lee, JH[Lee, Joon Hyeok]; Koh, KC[Koh, Kwang Cheol]; Yoo, BC[Yoo, Byung Chul]; Son, HJ[Son, Hee Jung]; Kim, SW[Kim, Seon Woo]
- Issue Date
- 14-Jan-2011
- Keywords
- Chronic hepatitis B; Chronic hepatitis C; Hepatitis A virus; Korea; Seroprevalence
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.17, no.2, pp.236 - 241
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 17
- Number
- 2
- Start Page
- 236
- End Page
- 241
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/70987
- DOI
- 10.3748/wjg.v17.i2.236
- ISSN
- 1007-9327
- Abstract
- AIM: To investigate the current seroprevalence of hepatitis A virus (HAV) antibodies in patients with chronic viral liver disease in Korea. We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS: We performed an analysis of the clinical records of 986 patients (mean age: 49 9 years, 714 males/272 females) with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009. RESULTS: The overall prevalence of IgG anti-HAV was 86.61% (854/986) in patients with chronic liver disease and was 88.13% (869/986) in age- and gender-matched patients from the Center for Health Promotion. The anti-HAV prevalence was 80.04% (405/506) in patients with chronic hepatitis B, 86.96% (20/23) in patients with chronic hepatitis C, 93.78% (422/450) in patients with HBV related liver cirrhosis, and 100% (7/7) in patients with HCV related liver cirrhosis. The anti-HAV prevalence according to the decade of age was as follows: 20s (6.67%), 30s (50.86%), 40s (92.29%), 50s (97.77%), and 60s (100%). The anti-HAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age. Multivariable analysis showed that age >= 40 years, female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION: Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus. (C) 2011 Baishideng. All rights reserved.
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