A New Scheme for Essential Protein Identification Based on Uncertain Networks
- Authors
- Liu, W[Liu, Wei]; Ma, LY[Ma, Liangyu]; Chen, L[Chen, Ling]; Jeon, B[Jeon, Byeungwoo]
- Issue Date
- 2020
- Publisher
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- Keywords
- Proteins; Gene expression; Prediction algorithms; Organisms; Matrix converters; Biological system modeling; Essential proteins; simrank algorithm; uncertain PPI network; biological information
- Citation
- IEEE ACCESS, v.8, pp.33977 - 33989
- Indexed
- SCIE
SCOPUS
- Journal Title
- IEEE ACCESS
- Volume
- 8
- Start Page
- 33977
- End Page
- 33989
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/7181
- DOI
- 10.1109/ACCESS.2020.2974897
- ISSN
- 2169-3536
- Abstract
- Identifying essential proteins is important for not only understanding cellular activity but also detecting human disease genes. A series of centrality measures have been proposed to identify essential proteins based on the protein-protein interaction (PPI) network. Although, existing studies have focused on the topological features of the PPI network and the intrinsic characteristics of biological attributes. it is still a big challenge to further improve the prediction accuracy of essential proteins. Moreover, there are substantial amounts of false-positive data in PPI networks; thus, a PPI network should be modelled as an uncertain network. How to identify essential proteins more accurately and conveniently has become a research hotspot. In this paper, we proposed a new essential protein discovery method called ETB-UPPI on uncertain PPI networks. The algorithm detects essential proteins by integrating topological features with biological information. Experimental results on four Saccharomyces cerevisiae datasets have shown that ETB-UPPI can not only improve the prediction accuracy but also outperform other prediction methods, including the most commonly-used centrality measures (DC, SC, BC, IC, EC, and NC), topology-based methods (LAC) and biological-data-integrating methods (PeC, WDC, UDONC, LBCC, TEGS, and RSG).
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Collections - Information and Communication Engineering > School of Electronic and Electrical Engineering > 1. Journal Articles
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