Epstein-Barr virus latent membrane protein 1 increases chemo-resistance of cancer cells via cytoplasmic sequestration of Pim-1
- Authors
- Kim, JH[Kim, Joo Hyun]; Kim, WS[Kim, Won Seog]; Yun, Y[Yun, Yungdae]; Park, C[Park, Chaehwa]
- Issue Date
- Dec-2010
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- LMP1; Pim-1; Epstein-Barr virus; Sequestration; Chemo-resistance; Cancer
- Citation
- CELLULAR SIGNALLING, v.22, no.12, pp.1858 - 1863
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR SIGNALLING
- Volume
- 22
- Number
- 12
- Start Page
- 1858
- End Page
- 1863
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/72773
- DOI
- 10.1016/j.cellsig.2010.07.013
- ISSN
- 0898-6568
- Abstract
- Improved treatment of EBV positive lymphoma depends on the identification of molecular mechanism underlying chemo-resistance. LMP1 is an essential transmembrane protein for EBV-induced immortalization of hematopoietic cells. Herein, we show that an oncogenic Pim-1 is translocated to the cytoplasm by LMP1. Three lines of evidence indicate that cytoplasmic sequestration of Pim-1 may be required for LMP1-induced cancer cell survival. First, Pim-1 enhanced the survival of LMP1-overexpressing cells treated with doxorubicin. Second, nuclear export of Pim-1 was sufficient to increase the survival. Third, knockdown of Pim-1 effectively suppressed LMP-1-induced survival of cancer cells. Collectively, these data suggest that Pim-1 is a downstream target of LMP1, and that it contributes to the chemo-resistance of cancer cells. (C) 2010 Elsevier Inc. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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