Detailed Information
Cited 16 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Two New Phenolic Amides from the Seeds of Pharbitis nil
- Issue Date
- Nov-2010
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Pharbitis nil; Convolvulaceae; phenolic amide; pharnilatin A; pharnilatin B; cytotoxicity
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.58, no.11, pp.1532 - 1535
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 58
- Number
- 11
- Start Page
- 1532
- End Page
- 1535
- ISSN
- 0009-2363
- Abstract
- Two new phenolic amides, pharnilatins A (1) and B (2), were isolated from the seeds of Pharbitis nil. These new compounds possess a p-coumaroyl unit with a structurally unique side chain, (2S,3S)-2,3-dihydroxyputrescine. The chemical structures and absolute stereochemistries of the new compounds were determined on the basis of spectroscopic analyses including 1D- and 2D-NMR experiments and chemical reactions. Compounds 1 and 2 exhibited cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cells. However, none of the compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated microglia cells.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.