Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study
- Authors
- Oh, SY[Oh, Sung Yong]; Kim, WS[Kim, Won Seog]; Kim, JS[Kim, Jin Seok]; Kim, SJ[Kim, Seok Jin]; Lee, S[Lee, Suee]; Lee, DH[Lee, Dae Ho]; Won, JH[Won, Jong-Ho]; Hwang, IG[Hwang, In Gyu]; Kim, MK[Kim, Min Kyoung]; Il Lee, S[Il Lee, Soon]; Chae, YS[Chae, Yee Soo]; Yang, DH[Yang, Deok-Hwan]; Kang, HJ[Kang, Hye Jin]; Choi, CW[Choi, Chul Won]; Park, J[Park, Jinny]; Kim, HJ[Kim, Hyo Jung]; Kwon, JH[Kwon, Jung Hye]; Lee, HS[Lee, Ho Sup]; Lee, GW[Lee, Gyeong-Won]; Eom, HS[Eom, Hyeon Seok]; Kwak, JY[Kwak, Jae-Yong]; Lee, WS[Lee, Won Sik]; Suh, C[Suh, Cheolwon]; Kim, HJ[Kim, Hyo-Jin]
- Issue Date
- Oct-2010
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Multiple; Mucosa-associated lymphoid tissues; Marginal zone; B cell lymphoma
- Citation
- INTERNATIONAL JOURNAL OF HEMATOLOGY, v.92, no.3, pp.510 - 517
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Volume
- 92
- Number
- 3
- Start Page
- 510
- End Page
- 517
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/73204
- DOI
- 10.1007/s12185-010-0680-z
- ISSN
- 0925-5710
- Abstract
- According to a previous review, multiple mucosa-associated lymphoid tissue (MALT)-organs involving marginal zone B cell lymphomas (MZLs) are present in 10-30% of patients. However, the clinical features and specific relationships among involved organs are yet to be clearly identified. In this study, we conducted retrospective analyses of multiple MALT organs involving MZLs (MM-MZLs) to identify their clinical features, treatment, prognosis, and specific relationships among involved organs. For analysis, between June 1987 and June 2009, a total of 55 patients from 17 different institutions in Korea, all of whom were histologically diagnosed with MM-MZL, were included in this study. MM-MZL was defined as MZL involving more than 2 different MALT organs. Multiple involvements within one MALT organ (e.g. both side ocular lesions, multiple lung nodules, and multiple stomach lesions, etc.) were excluded from this study. The male/female ratio of the 55 patients was 41/14. The median age of our subjects was 59 years (range 30-82 years). MM-MZL without lymph node (LN) was detected only in 9 patients (36.2%). Bone marrow (BM) involvement was observed in 17 patients (30.9%). The most common site of involvement was the gastrointestinal (GI) tract (25 patients, 45.5%) followed by the lung (40%), Waldeyer's ring (WR) (27.3%), and ocular area (25.5%). Ocular MZLs were commonly accompanied with WR- or lung-MZLs. GI-MZLs were WR or GI-MZLs. Lung-MZLs were frequently observed with ocular and GI-MZLs. WR-MZLs were ocular or GI-MZLs. A total of 53 patients were treated, and 2 on watchful wait. As much as 48 patients received chemotherapy-based treatment. Among them, CR or PR was achieved in 38 patients (79.2%, 95% CI 67-91%). Median time to progression (TTP) was 2.3 years (95% CI 1.4-3.2 years). Cause-specific overall survival (OS) did not reach the median value. The 5-year OS rate was 84.9%. MM-MZLs tend to be an indolent disease, characterized by prolonged survival with frequent relapses. The majority of cases could be controlled effectively via chemotherapy-based treatment, and prolonged survival was achieved in those patients. The GI, lung, WR, and ocular area were commonly presented with other MALT site MZLs, and an organ-specific relationship appears to be relevant to MM-MZLs.
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