Expression of COX-2 in Cells of Invasive Ductal Carcinoma and Adjacent Non-Cancerous Ductal Epithelia in Human Breastopen access
- Authors
- Kim, JH[Kim, Jun Ho]; Park, YL[Park, Yong Lai]
- Issue Date
- Sep-2010
- Publisher
- KOREAN SURGICAL SOCIETY
- Keywords
- Cyclooxygenase-2; HER2; Invasive ductal carcinoma
- Citation
- JOURNAL OF THE KOREAN SURGICAL SOCIETY, v.79, no.3, pp.180 - 188
- Indexed
- SCOPUS
- Journal Title
- JOURNAL OF THE KOREAN SURGICAL SOCIETY
- Volume
- 79
- Number
- 3
- Start Page
- 180
- End Page
- 188
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/73402
- DOI
- 10.4174/jkss.2010.79.3.180
- ISSN
- 2233-7903
- Abstract
- Purpose: Cyclooxygenase-2 (Cox-2) is an inducible enzyme that converts arachidonic acid to prostaglandins. Aberrant expression of Cox-2 and prostaglandins has been observed in many cancers, including colon and breast cancers, and 40% of human breast cancers show overexpression of Cox-2. The aim of this study was to analyze the role of Cox-2 expression in breast cancers. Methods: The expression of Cox-2 and HER2 was examined in 56 breast tissue samples including microscopically normal epithelium and invasive ductal carcinomas (IDC) using immunohistochemical (IHC) methods. Frozen breast cancers and adjacent non-cancerous tissue (ANCT) pairs (n=30) were analyzed for Cox-2 and HER2 mRNA expression by RT-PCR. The results were compared with the prognostic parameters of breast cancer including tumor grade, growth pattern, lymph node metastasis, estrogen receptor status and Ki-67 labeling index. Results: Cytoplasmic Cox-2 expression was detected in 39 of 56 (69.6%) IDC and the Cox-2 expression in IDC was closely associated with HER2 expression (P=0.023). However, the expression of Cox-2 was not associated with other prognostic parameters of breast cancer (P>0.05). The Cox-2 mRNA showed high expression levels in IDC (25/30, 83.3%) as well as ANCT (22/25, 88%). Conclusion: The association between the expression of Cox-2 and HER2 suggests that Her2/neu gene induces the Cox-2 expression in breast cancer and overexpression of Cox-2 is involved in breast cancer development. Though the cells of ANCT are normal in morphology, their molecular alteration (overexpression of Cox-2) suggests that these cells have transformed already. (J Korean Surg Soc 2010;79:180-188)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.