Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitalsopen access
- Authors
- Son, JS[Son, Jun Seong]; Song, JH[Song, Jae-Hoon]; Ko, KS[Ko, Kwan Soo]; Yeom, JS[Yeom, Joon Sup]; Ki, HK[Ki, Hyun Kyun]; Kim, SW[Kim, Shin-Woo]; Chang, HH[Chang, Hyun-Ha]; Ryu, SY[Ryu, Seong Yeol]; Kim, YS[Kim, Yeon-Sook]; Jung, SI[Jung, Sook-In]; Shin, SY[Shin, Sang Yop]; Oh, HB[Oh, Hee Bok]; Lee, YS[Lee, Yeong Seon]; Chung, DR[Chung, Doo Ryeon]; Lee, NY[Lee, Nam Yong]; Peck, KR[Peck, Kyong Ran]
- Issue Date
- Jul-2010
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Bloodstream infection; Bacteremia; Community-acquired; Hospital-acquired; Healthcare-associated
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.7, pp.992 - 998
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 25
- Number
- 7
- Start Page
- 992
- End Page
- 998
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/73818
- DOI
- 10.3346/jkms.2010.25.7.992
- ISSN
- 1011-8934
- Abstract
- Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. Escherichia coli was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, Staphylococcus aureus (15.2%), coagulase-negative Staphylococcus (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/73818)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.