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PYRROLIZIDINE ALKALOIDS FROM THE ROOTS OF PARIS VERTICILLATA
- Authors
- Kim, KH[Kim, Ki Hyun]; Lee, KH[Lee, Kyu Ha]; Choi, SU[Choi, Sang Un]; Kim, KR[Kim, Kyung Ran]; Lee, KR[Lee, Kang Ro]
- Issue Date
- 1-Jun-2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Paris verticillata; Liliaceae; Pyrrolizidine Alkaloid; Cytotoxicity
- Citation
- HETEROCYCLES, v.81, no.6, pp.1493 - 1502
- Indexed
- SCIE
SCOPUS
- Journal Title
- HETEROCYCLES
- Volume
- 81
- Number
- 6
- Start Page
- 1493
- End Page
- 1502
- ISSN
- 0385-5414
- Abstract
- Three new pyrrolizidine alkaloids, verticillatins A (1), B (2), and C (3), together with seven known pyrrolizidine alkaloids (4-10), were isolated from the roots of Paris verticillata (Liliaceae). Their structures were determined by spectroscopic data and chemical evidences. Verticillatin A (1), verticillatin B (2), verticillatin C (3), heliovinine N-oxide (4), and indicine N-oxide (5) showed cytotoxicity against the HCT15 cell line, with IC(50) values of 67.6, 92.4, 35.7, 36.2, and 74.7 mu M, respectively.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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