F-18-FDG uptake and its clinical relevance in primary gastric lymphoma
- Authors
- Yi, JH[Yi, Jun Ho]; Kim, SJ[Kim, Seok Jin]; Choi, JY[Choi, Joon Young]; Ko, YH[Ko, Young Hyeh]; Kim, BT[Kim, Byung-Tae]; Kim, WS[Kim, Won Seog]
- Issue Date
- Jun-2010
- Publisher
- WILEY-BLACKWELL
- Keywords
- lymphoma; stomach; PET
- Citation
- HEMATOLOGICAL ONCOLOGY, v.28, no.2, pp.57 - 61
- Indexed
- SCIE
SCOPUS
- Journal Title
- HEMATOLOGICAL ONCOLOGY
- Volume
- 28
- Number
- 2
- Start Page
- 57
- End Page
- 61
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/74091
- DOI
- 10.1002/hon.905
- ISSN
- 0278-0232
- Abstract
- We studied the clinical relevance of F-18-fluorodeoxyglucose (F-18-FDG) uptake in patients with primary gastric lymphoma underwent positron emission tomography (PET)/computed tomography (CT) scan. Forty-two patients with primary gastric lymphoma were analysed: 32 diffuse large B-cell lymphomas (DLBCL) and 10 extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas). The PET/CT scans were compared with clinical and pathologic features, and the results of CT and endoscopy. Nine patients were up-staged based on the results of their PET/CT scan compared to CT (seven DLBCLs, two MALT lymphomas) while six patients were down-staged by the PET/CT scan. The standard uptake value (SUV) was used as an indicator of a lesion with a high metabolic rate. The high SUVmax group, defined as an SUVmax >= median value, was significantly associated with an advanced Lugano stage (p < 0.001). Three patients with DLBCL, who showed an initially high SUVmax, died of disease progression. Among 24 patients for whom follow-up PET/CT scan with endoscopy was performed, 11 patients with ulcerative or mucosal lesions showed residual F-18-FDG uptake. All of these gastric lesions were grossly and pathologically benign lesions without evidence of lymphoma cells. In conclusion, PET/CT scan can be used in staging patients with primary gastric lymphoma; however, the residual F-18-FDG uptake observed during follow-up should be interpreted cautiously and should be combined with endoscopy and multiple biopsies of the stomach. Copyright (C) 2009 John Wiley & Sons, Ltd.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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