When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type?
- Authors
- Kim, SJ[Kim, S. J.]; Oh, SY[Oh, S. Y.]; Hong, JY[Hong, J. Y.]; Chang, MH[Chang, M. H.]; Lee, DH[Lee, D. H.]; Huh, J[Huh, J.]; Ko, YH[Ko, Y. H.]; Ahn, YC[Ahn, Y. C.]; Kim, HJ[Kim, H. -J.]; Suh, C[Suh, C.]; Kim, K[Kim, K.]; Kim, WS[Kim, W. S.]
- Issue Date
- May-2010
- Publisher
- OXFORD UNIV PRESS
- Keywords
- CNS disease; extranodal NK; T-cell lymphoma; prognosis; prophylaxis
- Citation
- ANNALS OF ONCOLOGY, v.21, no.5, pp.1058 - 1063
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 21
- Number
- 5
- Start Page
- 1058
- End Page
- 1063
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/74413
- DOI
- 10.1093/annonc/mdp412
- ISSN
- 0923-7534
- Abstract
- Patients and methods: We analyzed 208 patients to study the clinical features and outcomes of CNS disease in extranodal NK/T-cell lymphoma. Results: Twelve patients (5.76%, 12/208) experienced CNS disease during treatment or follow-up period (median 11.62 months, range 0.2-123.2 months). The clinical variables associated with CNS disease were Ann Arbor stage III/IV (15.87%, P < 0.001), regional lymph node involvement (10.41%, P = 0.006), group III/IV of NK/T-cell lymphoma prognostic index (NKPI; 10.20%, P = 0.003), high/high-intermediate international prognostic index (9.30%, P = 0.072) and extra-upper aerodigestive primary sites (9.75%, P = 0.008). In multivariate analysis, NKPI retained the strongest statistical power to predict CNS disease (P = 0.007, relative risk 9.289, 95% confidence interval 1.828-47.212) in extranodal NK/T-cell lymphoma. Conclusions: Despite extranodal NK/T-cell lymphoma frequently involves paranasal sinus, a routine CNS evaluation and prophylaxis do not seem to be necessary in NKPI group I or II patients due to a very low incidence. Nevertheless, CNS prophylaxis should be considered in NKPI groups III and IV.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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