Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps
- Authors
- Hwang, ST[Hwang, Sang Tae]; Cho, YK[Cho, Yong Kyun]; Park, JH[Park, Jung Ho]; Kim, HJ[Kim, Hong Joo]; Park, DI[Park, Dong Il]; Sohn, CI[Sohn, Chong Il]; Jeon, WK[Jeon, Woo Kyu]; Kim, BI[Kim, Byung Ik]; Won, KH[Won, Kyoung Hee]; Jin, W[Jin, Wook]
- Issue Date
- Mar-2010
- Publisher
- WILEY-BLACKWELL PUBLISHING, INC
- Keywords
- colorectal adenomatous polyp; non-alcoholic fatty liver disease
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.25, no.3, pp.562 - 567
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 25
- Number
- 3
- Start Page
- 562
- End Page
- 567
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/74822
- DOI
- 10.1111/j.1440-1746.2009.06117.x
- ISSN
- 0815-9319
- Abstract
- Background and Aims: Metabolic syndrome and insulin resistance are associated with a higher risk of colon cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver. This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps. Methods: We examined the 2917 participants who underwent a routine colonoscopy at Kangbuk Samsung Hospital in 2007. We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361). Anthropometric measurements, biochemical tests for liver and metabolic function, and abdominal ultrasonographs were assessed. Results: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group. By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60). An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps. Conclusion: NAFLD was associated with colorectal adenomatous polyps. Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
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