The Effect of Cyclooxygenase-2 Expression on Tumor Volume Response in Patients Treated with Radiotherapy for Uterine Cervical Canceropen access
- Authors
- Kang, MK[Kang, Min Kyu]; Park, W[Park, Won]; Choi, YL[Choi, Yoon-La]; Cho, EY[Cho, Eun Yoon]; Ahn, G[Ahn, Geunghwan]; Nam, H[Nam, HeeRim]; Huh, SJ[Huh, Seung Jae]; Ahn, YC[Ahn, Yong Chan]; Lim, DH[Lim, Do Hoon]; Oh, DR[Oh, Dong Ryul]; Bae, DS[Bae, Duk Soo]; Kim, BG[Kim, Byoung Gie]
- Issue Date
- Dec-2009
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.6, pp.1170 - 1176
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 24
- Number
- 6
- Start Page
- 1170
- End Page
- 1176
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/76448
- DOI
- 10.3346/jkms.2009.24.6.1170
- ISSN
- 1011-8934
- Abstract
- We investigated the correlation between Cyclooxygenase-2 (COX-2) expression and the tumor response in patients with cervical cancer that were treated with curative radiotherapy (RT). Fifty-seven patients with squamous cell carcinoma were treated with concurrent radiochemotherapy (CRCT, n=29) or RT alone (n=28). The response of each patient was evaluated by three serial Magnetic Resonance Imaging examinations: before the start of RT, at four weeks after the start of RT (mid-RT) and at four weeks after the completion of RT (post-RT). Forty-three patients had positive COX-2 expression. The COX-2 negative patients achieved a higher rate of complete response (CR) at mid-RT than did the COX-2 positive patients (28.6% vs. 7.0%, P=0.054), but not at post-RT (64.3% vs. 69.8%). The initial tumor volume was a significant predictor of CR at mid-RT (P=0.003) and post-RT (P=0.004). The multivariate analysis showed that the initial tumor volume (at mid-RT and post-RT) and CRCT (at post-RT) were significant predictors of CR; however, the COX-2 expression was not. In conclusion, the COX-2 expression status has no significant correlation with the tumor response. Further studies on the changes in COX-2 expression levels during RT may be helpful for determination of its role in the tumor response to treatment and patient prognosis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/76448)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.