Extracts from Rhizopus oryzae KSD-815 of Korean Traditional Nuruk Confer the Potential to Inhibit Hypertension, Platelet Aggregation, and Cancer Metastasis in vitro
- Authors
- Lee, SJ[Lee, Sang-Jin]; Bae, HJ[Bae, Hyun-Jin]; Ryu, J[Ryu, Jiyeon]; Lee, D[Lee, Daeyoung]; Kim, GW[Kim, Gye-Won]; Baek, N[Baek, Namin]; Kwon, M[Kwon, Moosik]; Hong, S[Hong, Sungyoul]
- Issue Date
- Dec-2009
- Publisher
- KOREAN SOC FOOD SCIENCE TECHNOLOGY
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.18, no.6, pp.1423 - 1429
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 18
- Number
- 6
- Start Page
- 1423
- End Page
- 1429
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/76475
- ISSN
- 1226-7708
- Abstract
- Rhizopus oryzae KSD-815 was isolated from nuruk that has been used to make Korean traditional wines. This study was performed to investigate the effect of cultures of R. oryzae KSD-815 on cardiovascular disorders and cancer metastasis. Firstly, these cultures were sequentially fractionationed with n-hexane (TAHe), ethylacetate (TAE), n-butanol (TAB), and H(2)O (TAW). The TAE inhibited the activity of angiotensin-converting enzyme (ACE) and TAB suppressed platelet aggregation in vitro. TAE and TAB inhibited cell motility of human breast cancer cells. Furthermore, TAW interrupted the fort-nation of neovasculature and tube-like structure, and down-regulated the expression of angiogenic factors, basic fibroblast growth factor (bFGF), tumor necrosis factor-alpha (TNF-alpha), and hypoxia-inducible factor-1 alpha (HIF-1 alpha) in breast cancer cells. These results indicated that Cultures of R. oryzae KSD-815 display the inhibitory activities on hypertension, platelet aggregation, and metastasis, and suggest that these cultures might be further probed for the purposes as therapeutic agents or dietary supplements.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/76475)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.