Pregnancy outcome of women transfused during pregnancy with blood products inadvertently obtained from donors treated with acitretin
- Authors
- Han, JY[Han, J. Y.]; Choi, JS[Choi, J. S.]; Chun, JM[Chun, J. M.]; Park, HD[Park, H. D.]; Lee, SY[Lee, S. Y.]; Kim, CH[Kim, C. H.]; Park, Q[Park, Q.]; Nava-Ocampo, AA[Nava-Ocampo, A. A.]; Koren, G[Koren, G.]
- Issue Date
- Nov-2009
- Publisher
- INFORMA HEALTHCARE
- Keywords
- Blood transfusions; drug safety; pregnancy outcome; transplacental exposure
- Citation
- JOURNAL OF OBSTETRICS AND GYNAECOLOGY, v.29, no.8, pp.694 - 697
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF OBSTETRICS AND GYNAECOLOGY
- Volume
- 29
- Number
- 8
- Start Page
- 694
- End Page
- 697
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/76680
- DOI
- 10.3109/01443610903177128
- ISSN
- 0144-3615
- Abstract
- We assessed the pregnancy outcome of nine women inadvertently transfused with acitretin-contaminated blood products in South Korea. A total of 18 women matched to cases by age, gravidity, and singleton- or twin-pregnancy, and who were transfused with blood products not contaminated with acitretin, was also recruited. There were nine babies born in the case group. No differences (p > 0.05) were observed between cases and controls in the gestational age at delivery (38.3 +/- 1.6 weeks vs 37.8 +/- 2.2 weeks), birth weight (3,146 +/- 874 g vs 3,106 +/- 568 g), rate of pre-term deliveries (22.2% vs 11.1%) and rate of low birth weight (<2,500 g) (33.3% vs 16.7%). There was no case of malformation or neurological abnormalities born in either group. In conclusion, inadvertent exposure to acitretin-contaminated blood products was not associated with adverse pregnancy outcomes, probably because of the removal of acitretin and etretinate during the manufacturing process of blood products.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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