Clinical significance of a serum CA15-3 surge and the usefulness of CA15-3 kinetics in monitoring chemotherapy response in patients with metastatic breast cancer
- Authors
- Kim, HS[Kim, Hyo Song]; Park, YH[Park, Yeon Hee]; Park, MJ[Park, Min Jae]; Chang, MH[Chang, Myung Hee]; Jun, HJ[Jun, Hyun Jung]; Kim, KH[Kim, Kyoung Ha]; Ahn, JS[Ahn, Jin Seok]; Kang, WK[Kang, Won Ki]; Park, K[Park, Keunchil]; Im, YH[Im, Young-Hyuck]
- Issue Date
- Nov-2009
- Publisher
- SPRINGER
- Keywords
- Tumor marker; CA 15-3; Breast cancer
- Citation
- BREAST CANCER RESEARCH AND TREATMENT, v.118, no.1, pp.89 - 97
- Indexed
- SCIE
SCOPUS
- Journal Title
- BREAST CANCER RESEARCH AND TREATMENT
- Volume
- 118
- Number
- 1
- Start Page
- 89
- End Page
- 97
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/76740
- DOI
- 10.1007/s10549-009-0377-2
- ISSN
- 0167-6806
- Abstract
- One hundred and twenty-two patients in whom the CA 15-3 level showed either a decline (92 patients) or an acute surge followed by a decline (30 patients) after chemotherapy were included. The clinical characteristics between the two groups and the CA 15-3 kinetics using receiver operating characteristic curves were analyzed. Patients with a surge had a significantly higher risk of disease progression than patients without a surge (P = 0.004; odds ratio 2.62; 95% CI 1.45-4.72). The clinicopathologic characteristics were significantly different between the two groups with respect to the distribution of ER, PR, and HER2 status, relapse-free survival, and the severity and extent of the involved organs. For patients with a surge, a CA 15-3 slope threshold > -0.0038 was chosen with a sensitivity of 80.0% and a specificity of 80.4%. The area under the curve was 0.847 (95% CI 0.771-0.906; P = 0.0001). A significant correlation between PFS and CA 15-3 slope was shown with Cox-regression modeling (P = 0.036; hazard ratio [HR], 2.1; 95% CI 1.01-4.14). These kinetics may serve as a good predictive marker of treatment response and response duration.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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