Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008
- Authors
- Cohen, JI[Cohen, J. I.]; Kimura, H[Kimura, H.]; Nakamura, S[Nakamura, S.]; Ko, YH[Ko, Y. -H.]; Jaffe, ES[Jaffe, E. S.]
- Issue Date
- Sep-2009
- Publisher
- OXFORD UNIV PRESS
- Keywords
- chronic active EBV infection; diffuse large B-cell lymphoma; hemophagocytic syndrome; hydroa vacciniforme; immune senescence; senile EBV-positive lymphoproliferative disease; systemic EBV-positive lymphoproliferative disease
- Citation
- ANNALS OF ONCOLOGY, v.20, no.9, pp.1472 - 1482
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 20
- Number
- 9
- Start Page
- 1472
- End Page
- 1482
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/77189
- DOI
- 10.1093/annonc/mdp064
- ISSN
- 0923-7534
- Abstract
- Design: To better define the pathogenesis, classification, and treatment of these disorders, participants from Asia, The Americas, Europe, and Australia presented clinical and experimental data at an international meeting. Results: The term systemic EBV-positive T-cell LPD, as adopted by the WHO classification, is preferred as a pathological classification over CAEBV (the favored clinical term) for those cases that are clonal. The disease has an aggressive clinical course, but may arise in the background of CAEBV. Hydroa vacciniforme (HV) and HV-like lymphoma represent a spectrum of clonal EBV-positive T-cell LPDs, which have a more protracted clinical course; spontaneous regression may occur in adult life. Severe mosquito bite allergy is a related syndrome usually of NK cell origin. Immune senescence in the elderly is associated with both reactive and neoplastic EBV-driven LPDs, including EBV-positive diffuse large B-cell lymphomas. Conclusion: The participants proposed an international consortium to facilitate further clinical and biological studies of novel EBV-driven LPDs.
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