Neuroblastoma Originating from Extra-abdominal Sites: Association with Favorable Clinical and Biological Featuresopen access
- Authors
- Sung, KW[Sung, Ki Woong]; Yoo, KH[Yoo, Keon Hee]; Koo, HH[Koo, Hong Hoe]; Kim, JY[Kim, Ju Youn]; Cho, EJ[Cho, Eun Joo]; Seo, YL[Seo, Yeon Lim]; Kim, J[Kim, Jhingook]; Lee, SK[Lee, Suk Koo]
- Issue Date
- Jun-2009
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Neuroblastoma; Prognosis; Thorax; Transplantation; Autologous
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.3, pp.461 - 467
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 24
- Number
- 3
- Start Page
- 461
- End Page
- 467
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/77719
- DOI
- 10.3346/jkms.2009.24.3.461
- ISSN
- 1011-8934
- Abstract
- Neuroblastomas originating from different sites might have different clinical and biological characteristics. In the present study, the clinical (age, sex and stage) and biological (N-myc amplification, Shimada pathology and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of patients with newly diagnosed neuroblastoma were compared according to the site of tumor origin (extra-abdominal versus abdominal). The event-free survival rate (EFS) was also compared between the two groups. Among 143 neuroblastomas, 115 tumors originated from the abdomen, 26 from extra-abdominal sites and 2 from unknown primary sites. Frequencies of stage 4 tumor and N-myc amplified tumor were lower in the extra-abdominal group than in the abdominal group (34.6% vs. 60.0%, P=0.019 and 4.2% vs. 45.0%, P<0.001, respectively). Levels of lactate dehydrogenase, ferritin and neuron-specific enolase were significantly lower in the extra-abdominal group than in the abdominal group. The probability of 5-yr EFS (+/- 95% confidence interval) was higher in the extra-abdominal group than in the abdominal group (94.4 +/- 10.6% vs. 69.4 +/- 9.4%, P=0.026). Taken together, neuroblastomas originating from extra-abdominal sites might be associated with more favorable clinical and biological characteristics and a better outcome than neuroblastomas originating from abdomen.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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