T-bet expression is regulated by EGR1-mediated signaling in activated T cells
- Authors
- Shin, HJ[Shin, Hyun-Jin]; Lee, JB[Lee, Jee-Boong]; Park, SH[Park, Sung-Hwan]; Chang, J[Chang, Jun]; Lee, CW[Lee, Chang-Woo]
- Issue Date
- Jun-2009
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- T-bet; EGR1; Promoter; Transcription; T helper cells; TCR signaling
- Citation
- CLINICAL IMMUNOLOGY, v.131, no.3, pp.385 - 394
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL IMMUNOLOGY
- Volume
- 131
- Number
- 3
- Start Page
- 385
- End Page
- 394
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/77773
- DOI
- 10.1016/j.clim.2009.02.009
- ISSN
- 1521-6616
- Abstract
- T-bet is a Th1-specific transcription factor that is directly involved in three important pathways for Th1 cell differentiation, namely TCR signaling, and the IFN-gamma-STAT1 and IL-12-STAT4 pathways. A recent study also showed that T-bet plays a vital role in innate immunity. However, the molecular mechanism responsible for transcriptional activation of T-bet during T cell development is not yet known. Here, we characterize the essential human T-bet promoter elements and show that binding of EGR1 to this promoter induces T-bet transcription. Notably, overexpression of EGR1 transactivates and, synergistically in concert with TCR signaling, induces T-bet expression in activated T cells. In contrast, depletion of EGR1 significantly decreases T-bet induction. Finally, we report a positive correlation between EGR1 and T-bet expression during T helper cell differentiation. Collectively, these findings provide molecular insight into T-bet transcription and suggest that EGR1 is an upstream regulator of T-bet induction. (C) 2009 Elsevier Inc. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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