Three-year clinical outcome of biodegradable hybrid polymer Orsiro sirolimus-eluting stent and the durable biocompatible polymer Resolute Integrity zotarolimus-eluting stent: A randomized controlled trialopen access
- Authors
- Kim, SH[Kim, Soo-Hyun]; Kang, SH[Kang, Si-Hyuck]; Lee, JM[Lee, Joo Myung]; Chung, WY[Chung, Woo-Young]; Park, JJ[Park, Jin Joo]; Yoon, CH[Yoon, Chang-Hwan]; Suh, JW[Suh, Jung-Won]; Cho, YS[Cho, Young-Seok]; Doh, JH[Doh, Joon-Hyung]; Cho, JM[Cho, Jin Man]; Bae, JW[Bae, Jang-Whan]; Youn, TJ[Youn, Tae-Jin]; Chae, IH[Chae, In-Ho]
- Issue Date
- Dec-2020
- Publisher
- WILEY
- Keywords
- biodegradable polymer; coronary artery disease; drug-eluting stents; percutaneous coronary intervention
- Citation
- CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, v.96, no.7, pp.1399 - 1406
- Indexed
- SCIE
SCOPUS
- Journal Title
- CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
- Volume
- 96
- Number
- 7
- Start Page
- 1399
- End Page
- 1406
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/7820
- DOI
- 10.1002/ccd.28654
- ISSN
- 1522-1946
- Abstract
- Aims We compared long-term clinical outcomes between patients treated with Orsiro sirolimus-eluting stent (O-SES) and those treated with durable biocompatible polymer Resolute Integrity zotarolimus-eluting stent (R-ZES). Methods and Results The ORIENT trial was a randomized controlled noninferiority trial to compare angiographic outcomes between O-SES and R-ZES. We performed a post hoc analysis of 3-year clinical outcomes and included 372 patients who were prospectively enrolled and randomly assigned to O-SES (n = 250) and R-ZES (n = 122) groups in a 2:1 ratio. The primary endpoint was target lesion failure defined as a composite of cardiac death, nonfatal myocardial infarction, and target lesion revascularization. At 3 years, target lesion failure occurred in 4.7% and 7.8% of O-SES and R-ZES groups, respectively (hazard ratio, 0.58; 95% confidence intervals, 0.24-1.41; p = .232 by log-rank test). Secondary endpoints including cardiac death, myocardial infarction, and target lesion revascularization showed no significant differences between the groups. Stent thrombosis occurred in two patients in R-ZES group (0.0% vs. 1.6%, p = .040). Conclusion This study confirms long-term safety and efficacy of the two stents. We found a trend for lower target lesion failure with O-SES compared to R-ZES, although statistically insignificant.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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