Uterine Leiomyosarcoma: 14-year Two-center Experience of 31 Cases
- Authors
- Kim, WY[Kim, Woo Young]; Chang, SJ[Chang, Suk-Joon]; Chang, KH[Chang, Ki-Hong]; Yoon, JH[Yoon, Jong-Hyuck]; Kim, JH[Kim, Jang Hee]; Kim, BG[Kim, Byoung-Gie]; Bae, DS[Bae, Duk-Soo]; Ryu, HS[Ryu, Hee-Sug]
- Issue Date
- Mar-2009
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Stage; Mitotic count; Adjuvant therapy; Prognostic factor
- Citation
- CANCER RESEARCH AND TREATMENT, v.41, no.1, pp.24 - 28
- Indexed
- SCIE
KCI
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 41
- Number
- 1
- Start Page
- 24
- End Page
- 28
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/78414
- DOI
- 10.4143/crt.2009.41.1.24
- ISSN
- 1598-2998
- Abstract
- Purpose The aim of this study was to evaluate the clinicopathological characteristics of uterine leiomyosarcoma (LMS) and possible prognostic factors. Materials and Methods This study included 31 patients with histologically proven LMS at Samsung Medical Center and Ajou University Hospital between 1994 and 2007. The medical records and available histological slides were reviewed retrospectively. Results The median age was 46 years (range, 32 similar to 63). The most common symptom was vaginal bleeding (11 patients, 35.5%). There were 23 patients with stage I, one patient with stage III, seven patients with stage IV disease. The median follow up time was 29 months (range, 1 similar to 94). The most common recurrence site was lung (5 case), followed by pelvis and upper abdomen (2 case). Nine patients died of disease with a 5-year overall survival rate of 63%. Early tumor stage and mitotic count were the prognostic factor in univariate analysis (p<0.0001 and p=0.0031, respectively), but early tumor stage only was associated with prognosis in multivariate analysis (p=0.010 vs p=0.143). Adjuvant treatment for early stage disease did not decrease the recurrence rate (p=0.1075), but high mitotic count (15>10HPF) had a trend for disease recurrence in early stage LMS (p=0.0859). Conclusion Mitotic count less than 15/HPF in early stage may be related with longer progression-free interval, but we could not reach the conclusion that adjuvant therapy in early stage LMS be effective.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.