Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition
- Authors
- Choi, SJ[Choi, Suk-Joo]; Jung, KL[Jung, Kyung-Lan]; Oh, SY[Oh, Soo-young]; Kim, JH[Kim, Jong-Hwa]; Roh, CR[Roh, Cheong-Rae]
- Issue Date
- Jan-2009
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Matrix metalloproteinase-9; Cervicovaginal fluid; Cervical ripening; Term labor; Premature rupture of membranes
- Citation
- EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.142, no.1, pp.43 - 47
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
- Volume
- 142
- Number
- 1
- Start Page
- 43
- End Page
- 47
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/78788
- DOI
- 10.1016/j.ejogrb.2008.08.009
- ISSN
- 0301-2115
- Abstract
- Objective: To investigate the changes of matrix metalloproteinase-9 (MMP-9) in cervicovaginal fluid during pregnancy and its association with parturition. Study design: A prospective study was conducted on nulliparous women between 16 and 42 weeks with normal singleton pregnancies in the following categories: (1) preterm control (n = 39): (2) term labor induction without labor or rupture of membranes (n = 68); (3) term spontaneous labor with intact membranes (n = 42); (4) term premature rupture of membranes (n = 24). The MMP-9 concentration in the cervicovaginal fluid was measured by immunoassay. Results: (1) Cervicovaginal MMP-9 did not change significantly with advancing gestation until 37 weeks, and significantly increased after 37 weeks. (2) Cervicovaginal MMP-9 levels were similar in women with no labor, spontaneous labor, and premature rupture of membranes at term. (3) For the induced labor group, a high Bishop score (>= 4) was significantly correlated with cervicovaginal MMP-9. However, an elevated cervicovaginal MMP-9 did not predict achieving active phase of labor or vaginal delivery after labor induction. Conclusion: Cervicovaginal MMP-9 correlated with cervical ripening before labor at term. However, cervicovaginal MMP-9 did not change with spontaneous labor or rupture of membranes at term and did not predict success of labor induction. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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