Extracts from Rhizopus oryzae KSD-815 of Korean traditional nuruk confer the potential to inhibit hypertension, platelet aggregation, and cancer metastasis in vitro
- Authors
- Lee, S.-J.[Lee, S.-J.]; Bae, H.-J.[Bae, H.-J.]; Ryu, J.[Ryu, J.]; Lee, D.[ Lee, D.]; Kim, G.-W.[ Kim, G.-W.]; Baek, N.[ Baek, N.]; Kwon, M.[Kwon, M.]; Hong, S.[Hong, S.]
- Issue Date
- 2009
- Keywords
- Anti-hypertension; Anti-metastatic activity; Korean traditional nuruk; Platelet aggregation; Rhizopus oryzae KSD-815
- Citation
- Food Science and Biotechnology, v.18, no.6, pp.1423 - 1429
- Indexed
- SCOPUS
KCI
- Journal Title
- Food Science and Biotechnology
- Volume
- 18
- Number
- 6
- Start Page
- 1423
- End Page
- 1429
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/79535
- ISSN
- 1226-7708
- Abstract
- Rhizopus oryzae KSD-815 was isolated from nuruk that has been used to make Korean traditional wines. This study was performed to investigate the effect of cultures of R. oryzae KSD-815 on cardiovascular disorders and cancer metastasis. Firstly, these cultures were sequentially fractionationed with n-hexane (TAHe), ethylacetate (TAE), n-butanol (TAB), and H 2 O (TAW). The TAE inhibited the activity of angiotensin-converting enzyme (ACE) and TAB suppressed platelet aggregation in vitro. TAE and TAB inhibited cell motility of human breast cancer cells. Furthermore, TAW interrupted the formation of neo- vasculature and tube-like structure, and down-regulated the expression of angiogenic factors, basic fibroblast growth factor (bFGF), tumor necrosis factor-α (TNF-α), and hypoxia-inducible factor-1α (HIF-1α) in breast cancer cells. These results indicated that cultures of R. oryzae KSD-815 display the inhibitory activities on hypertension, platelet aggregation, and metastasis, and suggest that these cultures might be further probed for the purposes as therapeutic agents or dietary supplements. © The Korean Society of Food Science and Technology.
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Collections - Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
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