Clinicopathological implications of EpCAM expression in adenocarcinoma of the lung
- Authors
- Kim, Y.[Kim, Y.]; Hyo, S.K.[ Hyo, S.K.]; Zheng, Y.C.[ Zheng, Y.C.]; Lee, H.-S.[ Lee, H.-S.]; Jin, S.A.[Jin, S.A.]; Chan, K.P.[ Chan, K.P.]; Park, K.[Park, K.]; Ahn, M.-J.[Ahn, M.-J.]
- Issue Date
- 2009
- Keywords
- EpCAM; Lung; Neoplasms
- Citation
- Anticancer Research, v.29, no.5, pp.1817 - 1822
- Indexed
- SCOPUS
- Journal Title
- Anticancer Research
- Volume
- 29
- Number
- 5
- Start Page
- 1817
- End Page
- 1822
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/79668
- ISSN
- 0250-7005
- Abstract
- Background: The frequency of epithelial cell adhesion molecule (EpCAM) expression was investigated in non-small cell lung cancer (NSCLC) cells and human tissues, and its clinicopathological significance in adenocarcinoma of the lung was evaluated. Materials and Methods: EpCAM expression was analysed by reverse transcription-polymerase chain reaction (RT-PCR) and flow cytometry in human NSCLC cells. EpCAM protein expression was evaluated in 234 adenocarcinoma tissues using immunohistochemistry. Results: A high expression level of EpCAM was observed in human NSCLC cells by flow cytometry and RT-PCR. EpCAM overexpression was detected in 120/234 (51.3%) surgically resected adenocarcinoma tissues. EpCAM overexpression occurred significantly more frequently in adenocarcinoma than in bronchioloalveolar carcinoma (p=0.02). The overall survival did not differ significantly between EpCAM-overexpressing and EpCAM-negative patients (p=0.40). Conclusion: These findings suggest EpCAM plays a role in the carcinogenesis of adenocarcinoma of the lung and might provide a promising molecule for targeted therapy in NSCLC.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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