Oncologic Outcomes of Nipple-Sparing Mastectomy with Immediate Breast Reconstruction in Patients with Tumor-Nipple Distance Less than 2.0 cmopen access
- Authors
- Alsharif, E[Alsharif, Emad]; Ryu, JM[Ryu, Jai Min]; Choi, HJ[Choi, Hee Jun]; Nam, SJ[Nam, Seok Jin]; Kim, SW[Kim, Seok Won]; Yu, J[Yu, Jonghan]; Chae, BJ[Chae, Byung Joo]; Lee, SK[Lee, Se Kyung]; Lee, JE[Lee, Jeong Eon]
- Issue Date
- Dec-2019
- Publisher
- KOREAN BREAST CANCER SOC
- Keywords
- Breast neoplasms; Prognosis; Subcutaneous mastectomy
- Citation
- JOURNAL OF BREAST CANCER, v.22, no.4, pp.613 - 623
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF BREAST CANCER
- Volume
- 22
- Number
- 4
- Start Page
- 613
- End Page
- 623
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/7996
- DOI
- 10.4048/jbc.2019.22.e48
- ISSN
- 1738-6756
- Abstract
- Purpose: Although the indications for nipple-sparing mastectomy (NSM) are expanding, there remains a debate regarding the oncologic outcomes of patients treated with this method, especially those with a short tumor-nipple distance (STND). The aim of this study was to compare the long-term oncologic outcomes between patients with a long tumor-nipple distance (LTND) (>= 2.0 cm) and those with STND (< 2.0 cm). Methods: This was a retrospective study in which 266 patients who underwent NSM with immediate breast reconstruction between January 2008 and December 2014 at a single institution were enrolled. Of these patients, 21 were excluded because of loss to follow-up; thus, 245 patients were finally analyzed. All patients underwent preoperative breast magnetic resonance imaging and intraoperative frozen biopsy. Results: The mean age of the patients was 42.4 years. STND was identified in 128 patients, and LTND in 117 patients. The mean follow-up period was 60.5 months. There were no significant differences between the 2 groups with respect to lymphovascular invasion, nuclear grade, nodal status, and subtype (p = 0.339, 0.372, 0.955, and 0.338, respectively). The STND group had significantly smaller tumors than the LTND group (p = 0.005). The median TND in the STND and LTND groups was 0.7 cm and 3.0 cm, respectively. Locoregional recurrence was reported in 4 patients in the STND group (3.1%) and 6 (5.1%) in the LTND group. A total of 3 patients died (1.2%; 2 in the STND group and one in the LTND group). There was no significant difference between the 2 groups with respect to disease-free survival or local recurrence-free survival (p = 0.334 and p = 0.477, respectively). Conclusion: The long-term oncologic outcomes of patients treated with NSM did not significantly differ according to TND when the intraoperative frozen biopsy was negative for tumor cells.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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