FDG PET/CT and Mediastinal Nodal Metastasis Detection in Stage T1 Non-Small Cell Lung Cancer: Prognostic Implications
- Authors
- Shin, KM[Shin, Kyung Min]; Lee, KS[Lee, Kyung Soo]; Shim, YM[Shim, Young Mog]; Kim, J[Kim, Jhingook]; Kim, BT[Kim, Byung-Tae]; Kwon, OJ[Kwon, O. Jung]; Park, K[Park, Keunchil]
- Issue Date
- Nov-2008
- Publisher
- KOREAN RADIOLOGICAL SOC
- Citation
- KOREAN JOURNAL OF RADIOLOGY, v.9, no.6, pp.481 - 489
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Volume
- 9
- Number
- 6
- Start Page
- 481
- End Page
- 489
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/80300
- DOI
- 10.3348/kjr.2008.9.6.481
- ISSN
- 1229-6929
- Abstract
- Objective: We aimed to compare the prognoses of patients with pathologically true negative (P-TN) N2 and PET/CT false negative (FN) results in stage T1 non-small cell lung cancer (NSCLC). Materials and Methods: Our institutional review board approved this retrospective study with a waiver of informed consent. The study included 184 patients (124 men and 60 women; mean age, 59 years) with stage T1 NSCLC who underwent an integrated PET/CT and surgery. After estimating the efficacy of PET/CT for detecting N2 disease, we determined and compared disease-free survival (DFS) rates in three groups (P-TN [n = 161], PET/CT FN [n = 12], and PET/CT true positive [TP, n = 11]) using the Kaplan-Meier analysis and log-rank test. Results: Pathologic N2 disease was observed in 23 (12%) patients. PET/CT had an N2 disease detection sensitivity of 48% (11 of 23 patients), a specificity of 95% (153 of 161), and an accuracy of 89% (164 of 184). The 3-year DFS rate in the PET/CT FN group (31%, 95% confidence interval [CI]; 13.6-48.0%) was similar to that of the TP group (16%, 95% CI; 1.7-29.5%) (p = 0.649), but both groups had significantly shorter DFS rates than the P-TN group (77%, 95% CI; 72.0-81.2%) (p < 0.001). Conclusion: The PET/CT shows a high specificity, but low sensitivity for detecting N2 disease in stage T1 NSCLC. Patients with PET/CT FN N2 disease have survival rates similar to PET/CT TP N2 disease patients, which are both substantially shorter than the survival rate of P-TN patients.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/80300)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.