Growth effects of botulinum toxin type A injected into masseter muscle on a developing rat mandible
- Authors
- Kim, JY[Kim, J-Y]; Kim, ST[Kim, S-T]; Cho, SW[Cho, S-W]; Jung, HS[Jung, H-S]; Park, KT[Park, K-T]; Son, HK[Son, H-K]
- Issue Date
- Oct-2008
- Publisher
- WILEY-BLACKWELL
- Citation
- ORAL DISEASES, v.14, no.7, pp.626 - 632
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORAL DISEASES
- Volume
- 14
- Number
- 7
- Start Page
- 626
- End Page
- 632
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/80472
- DOI
- 10.1111/j.1601-0825.2007.01435.x
- ISSN
- 1354-523X
- Abstract
- OBJECTIVES: Botulinum toxin type A (BTX-A) reduces the muscular contractions by temporarily inhibiting the release of acetylcholine at the neuromuscular junction. The purpose of this study was to investigate the effects of the BTX-A injected into the masseter muscle of a developing rat mandible. MATERIALS AND METHODS: Four-week-old male (no. 80) Sprague-Dawley rats were divided into four groups: control group, saline group, BTX-A group and baseline control group. Rats of baseline group were sacrificed at 0 day to provide baseline values of the mandibular measurements. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Experimental animals were sacrificed after 4 weeks. RESULTS: The BTX-A group demonstrated smaller mandibular dimension compared with the other groups (P < 0.05). Their condylar cartilages showed increased apoptosis at the proliferation stage of the reserve zone and masseter muscle fibers demonstrated atrophic changes. CONCLUSIONS: The result demonstrated BTX-A influence on inhibitory action of the developing mandible because of apoptosis at the proliferation stage of the reserve zone of the condylar cartilage in developing rat mandible.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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