Different clinical and magnetic resonance imaging features between Charcot-Marle-Tooth disease type 1A and 2A
- Authors
- Chung, KW[Chung, K. W.]; Suh, BC[Suh, B. C.]; Shy, ME[Shy, M. E.]; Cho, SY[Cho, S. Y.]; Yoo, JH[Yoo, J. H.]; Park, SW[Park, S. W.]; Moon, H[Moon, H.]; Park, KD[Park, K. D.]; Choi, KG[Choi, K. G.]; Kim, S[Kim, S.]; Kim, SB[Kim, S. B.]; Shim, DS[Shim, D. S.]; Kim, SM[Kim, S. M.]; Sunwoo, IN[Sunwoo, I. N.]; Choi, BO[Choi, B. O.]
- Issue Date
- Aug-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Charcot-Marie-Tooth disease; PMP22; mitofusin 2; magnetic resonance imaging; fatty infiltration
- Citation
- NEUROMUSCULAR DISORDERS, v.18, no.8, pp.610 - 618
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROMUSCULAR DISORDERS
- Volume
- 18
- Number
- 8
- Start Page
- 610
- End Page
- 618
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/80927
- DOI
- 10.1016/j.nmd.2008.05.012
- ISSN
- 0960-8966
- Abstract
- Charcot-Marie-Tooth disease type 1A (CMT1A) is the more frequent cause of demyelinating CMT, and CMT2A is the most common Cause of axonal CMT. We conducted a magnetic resonance imaging (MRI) study on 39 CMT1A and 21 CMT2A patients to compare their neuroimaging patterns and correlate with clinical features. CMT1A patients showed selective fatty infiltration with a preference for anterior and lateral compartment muscles, whereas CMT2A patients showed a preference for superficial posterior compartment muscles. Early-onset CMT2A patients showed more severe leg fatty atrophy than late-onset CMT2A patients. In late-onset CMT2A, soleus muscle was the earliest, and most severely affected than the other leg muscles. Selective involvement of intrinsic foot muscles is a characteristic pattern of minimal CMT1A and CMT2A. Our MRI Study demonstrates different patterns of fatty infiltration involving superficial posterior compartment muscles in CMT2A (partial T-type), and peroneal nerve innervated muscles in CMT1A (P-type). (C) 2008 Elsevier B.V. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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