MCP-1 derived from stromal keratocyte induces corneal infiltration of CD4(+) T cells in herpetic stromal keratitis
- Authors
- Lee, SK[Lee, Sun Kyoung]; Choi, BK[Choi, Beom Kyu]; Kang, WJ[Kang, Woo Jin]; Kim, YH[Kim, Young Ho]; Park, HY[Park, Hye Young]; Kim, KH[Kim, Kwang Hui]; Kwon, BS[Kwon, Byoung S.]
- Issue Date
- 31-Jul-2008
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- chemokine; cytokine; herpes simplex virus type 1 (HSV-1)
- Citation
- MOLECULES AND CELLS, v.26, no.1, pp.67 - 73
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 26
- Number
- 1
- Start Page
- 67
- End Page
- 73
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/81037
- ISSN
- 1016-8478
- Abstract
- Herpetic stromal keratitis (HSK) is an inflammatory disorder induced by HSV-1 infection and characterized by T cell-dependent destruction of corneal tissues. It is not known what triggers CD4(+) T cell migration into the stroma of HSV-1-infected corneas. The keratocyte is a fibroblast-like cell that can function as an antigen-presenting cell in the mouse cornea by expressing MHC class II and costimulatory molecules after HSV-1 infection. We hypothesized that chemokines produced by stromal keratocytes; are involved in CD4(+) T cell infiltration into the cornea. We found that keratocytes produce several cytokines and chemokines, including MCP-1, RANTES, and T cell activation (TCA)-3. HSV-1 infection increased the production of MCP-1 and RANTES by keratocytes, and these acted as chemoattractants for HISV-1-primed CD4(+) T cells expressing CCR2 and CCR5. Expression of MCP-1 in the corneal stroma was confirmed in vivo. Finally, when HSV-1-primed CD4(+) T cells were adoptively transferred into wild type and MCP-1-deficient mice that had been sublethally irradiated to minimize chemokine production from immune cells, infiltration of CD4(+) T cells was markedly reduced in the MCP-1-deficient mice, suggesting that it is the MCP-1 from HSV-1-infected keratocytes that attracts CD4(+) T cells into the cornea.
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Collections - SKKU Institute for Convergence > Biomedical Engineering > 1. Journal Articles
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