Evaluation of ER and Ki-67 proliferation index as prognostic factors for survival following neoadjuvant chemotherapy with doxorubicin/docetaxel for locally advanced breast cancer
- Authors
- Lee, J[Lee, J.]; Im, YH[Im, Y. H.]; Lee, SH[Lee, S. H.]; Cho, EY[Cho, E. Y.]; Choi, YL[Choi, Y. L.]; Ko, YH[Ko, Y. H.]; Kim, JH[Kim, J. H.]; Nam, SJ[Nam, S. J.]; Kim, HJ[Kim, H. J.]; Ahn, JS[Ahn, J. S.]; Park, YS[Park, Y. S.]; Lim, HY[Lim, H. Y.]; Han, BK[Han, B. K.]; Yang, JH[Yang, J. H.]
- Issue Date
- Apr-2008
- Publisher
- SPRINGER
- Keywords
- Ki-67 proliferation index; breast cancer; neoadjuvant chemotherapy
- Citation
- CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.61, no.4, pp.569 - 577
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Volume
- 61
- Number
- 4
- Start Page
- 569
- End Page
- 577
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/81764
- DOI
- 10.1007/s00280-007-0506-8
- ISSN
- 0344-5704
- Abstract
- Background The aim of the study was to identify reliable predictive biological markers for treatment outcome following neoadjuvant adriamycin/docetaxel (AT) chemotherapy in locally advanced breast cancer patients. Materials and methods This study was a phase II study on AT neoadjuvant chemotherapy in locally advanced breast cancer patients. Patients received 50 mg/m(2) of doxorubicin intravenously (IV) over 15 min followed by docetaxel 75 mg/m(2) infused over 1 h, repeated every 3 weeks for three cycles. Surgery was performed within 3-4 weeks following the last cycle of chemotherapy. We analyzed the pre-treatment and post-treatment expression levels of ER, PgR, HER-2, Ki-67 proliferation index, and p53 and examined the correlation between the markers and clinical parameters with treatment response, overall survival and relapse-free survival following neoadjuvant treatment. Results From July 2001 to September 2004, 61 patients were enrolled. The meaningful parameters adversely influencing survival were post-treatment ER(-) status (P = 0.013) and post-treatment Ki-67 index above 1.0% (P = 0.013). At the multivariate level, the post-treatment Ki-67 proliferation index <= 1.0 was the only meaningful prognostic factor for better survival (P = 0.033). Notably, tumors with Ki-67 index <= 1.0 were more likely to express ER with statistical significance (P = 0.002). Tumors with ER(+) and Ki-67 index <= 1.0 showed the highest survival rate, followed by ER(+) and Ki-67 index > 1.0%, ER(-) and Ki-67 <= 1.0%, and ER(-) and Ki-67 > 1.0% with the worst survival (P = 0.033). Conclusion Collectively, post-treatment ER status and Ki-67 proliferation index were prognostic of overall survival following neoadjuvant AT chemotherapy.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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