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Stereoselective total synthesis of (1S,3R)-3-hydroxypipecolic acid
- Authors
- Pham, VT[Pham, Van-Thoai]; Joo, JE[Joo, Jae-Eun]; Tian, YS[Tian, Yong-Shou]; Chung, YS[Chung, Yun-Sung]; Lee, KY[Lee, Kee-Young]; Oh, CY[Oh, Chang-Young]; Ham, WH[Ham, Won-Hun]
- Issue Date
- 19-Feb-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- TETRAHEDRON-ASYMMETRY, v.19, no.3, pp.318 - 321
- Indexed
- SCIE
SCOPUS
- Journal Title
- TETRAHEDRON-ASYMMETRY
- Volume
- 19
- Number
- 3
- Start Page
- 318
- End Page
- 321
- ISSN
- 0957-4166
- Abstract
- A concise, stereocontrolled synthesis of (2S,3R)-3-hydroxypipecolic acid 1 is described. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0) and intramolecular cyclization by catalytic hydrogenation of an oxazoline. (C) 2008 Elsevier Ltd. All rights reserved.
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