Preparation of micro-fabricated biodegradable polymeric structures using NCDS
- Authors
- Lee, JH[Lee, Jae-Hoon]; Ha, WS[Ha, Won-Shik]; Chu, WS[Chu, Won-Shik]; Park, CW[Park, Chun-Woong]; Ahn, SH[Ahn, Sung-Hoon]; Chi, SC[Chi, Sang-Cheol]
- Issue Date
- Jan-2008
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- 5-fluorouracil; PLGA; hydroxyapatite; micro-fabrication
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.31, no.1, pp.125 - 132
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 31
- Number
- 1
- Start Page
- 125
- End Page
- 132
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/82325
- DOI
- 10.1007/s12272-008-1130-9
- ISSN
- 0253-6269
- Abstract
- PLGA scaffolds were prepared using a nano-composite deposition system (NCDS). 5-Fluorouracil (5-FU) was used as a model drug. Hydroxyapatite (HA) was included in the scaffolds to improve the mechanical properties of the scaffolds and modulate the release of 5-FU from the scaffolds. 5-FU and HA were dispersed well in the prepared scaffolds when evaluated with SEM, FT-IR, XRPD and IDSC. The release of 5-FU from the prepared scaffolds consisting of different compositions was determined using 40 mL PBS as the medium. The release profiles of 5-FU from PLGA scaffolds followed the typical triphasic release pattern. The addition of HA to the compositions increased the release rate of 5-FU from the scaffolds and improved the mechanical properties of the scaffolds, while it retarded the degradation of PLGA. Therefore, NCDS could be a good system to prepare polymeric implants of various shapes with different drug release patterns.
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- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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