The effects of atorvastatin on the occurrence of postoperative atrial fibrillation after off-pump coronary artery bypass grafting surgery
- Authors
- Song, Y.B.[Song, Y.B.]; On, Y.K.[On, Y.K.]; Kim, J.H.[ Kim, J.H.]; Shin, D.-H.[ Shin, D.-H.]; Kim, J.S.[Kim, J.S.]; Sung, J.[Sung, J.]; Lee, S.H.[Lee, S.H.]; Kim, W.S.[Kim, W.S.]; Lee, Y.T.[Lee, Y.T.]
- Issue Date
- 2008
- Citation
- American Heart Journal, v.156, no.2, pp.373.e9 - 373.e16
- Indexed
- SCOPUS
- Journal Title
- American Heart Journal
- Volume
- 156
- Number
- 2
- Start Page
- 373.e9
- End Page
- 373.e16
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/83194
- DOI
- 10.1016/j.ahj.2008.04.020
- ISSN
- 0002-8703
- Abstract
- Background: Atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery is still the most common arrhythmic complication. This study evaluated whether pretreatment with atorvastatin protects against AF after off-pump CABG. Methods: One hundred twenty-four patients without a history of AF or previous statin use, who were scheduled to undergo elective off-pump CABG, were enrolled. Patients were randomized to control group (n = 62) or to atorvastatin group (n = 62) who were administered atorvastatin 20 mg/d for 3 days before the surgery. Primary outcome was the incidence of postoperative AF. Secondary outcomes were major adverse cardiac and cerebrovascular events, persistent AF at 1 month, and identification of the markers to predict inhospital postoperative AF. Results: The incidence of AF was significantly lower in the atorvastatin group than in the control group (13% vs 27%, P = .04). The incidence of major adverse cardiac and cerebrovascular events and persistent AF at 1 month was similar in comparisons between the groups. Postoperative peak N-terminal pro-brain natriuretic peptide levels were significantly higher in the patients with AF (P = .03). Multivariate analysis identified pretreatment with atorvastatin as an independent factor associated with a significant reduction in postoperative AF (odds ratio 0.34, P = .04). Higher postoperative peak N-terminus pro-B-type natriuretic peptide levels were associated with the development of postoperative AF (odds ratio 1.02 per 100 pg/mL, P = .03). Conclusions: Pretreatment with atorvastatin significantly reduced the occurrence of postoperative AF after off-pump CABG. © 2008 Mosby, Inc. All rights reserved.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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