HMCO5, herbal extract, inhibits NF-kappa B expression in lipopolysaccharide treated macrophages and reduces atherosclerotic lesions in cholesterol fed mice
- Authors
- Kim, KM[Kim, Ki Mo]; Choi, JY[Choi, Jin Yong]; Yoo, SE[Yoo, Si-Eun]; Park, MY[Park, Mi Young]; Lee, BS[Lee, Bok-Soo]; Ko, YH[Ko, Young Hye]; Sung, SH[Sung, Sang Hyun]; Shin, HM[Shin, Heung-Mook]; Park, JE[Park, Jeong Euy]
- Issue Date
- 3-Dec-2007
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- HMCO5; herb; atherosclerosis; inflammatory cytokines; NF-kappa B; animal model
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.114, no.3, pp.316 - 324
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 114
- Number
- 3
- Start Page
- 316
- End Page
- 324
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/83440
- DOI
- 10.1016/j.jep.2007.08.029
- ISSN
- 0378-8741
- Abstract
- HMCO5 is a herbal extract which comprises of eight different herbs. We studied whether this extract has anti-atherosclerotic effects. In lipopolysaccharide (LPS) stimulated RAW264.7 cells, HMCO5 inhibited NF-kappa B activation as well as NOS promoter activity, inhibited the secretion of TNF-alpha. and IL-1 beta, and directly inhibited the intracellular accumulation of reactive oxygen species. ApoE knock-out mice fed a high-fat high-cholesterol diet with HMCO05 for 10 weeks showed a significant reduction in atherosclerotic lesions. A notable finding was the preservation of the smooth muscle cell layer in the media of aorta in the HMCO5 co-treated mice. HMCO5 treated mice did not show significant decrease in serum level of cholesterol. These results suggest that HMC05 has anti-atherosclerotic effects which in part may be attributable to the inhibition of production of NF-kappa B dependent pro-inflammatory cytokines. (c) 2007 Published by Elsevier Ireland Ltd.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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