Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation
- Authors
- Lee, HS[Lee, Hae Sung]; Jung, KK[Jung, Ki Kyung]; Cho, JY[Cho, Jae Youl]; Rhee, MH[Rhee, Man Hee]; Hong, S[Hong, Sungyoul]; Kwon, M[Kwon, Moosik]; Kim, SH[Kim, Seung Hee]; Kang, SY[Kang, Seog Youn]
- Issue Date
- Dec-2007
- Publisher
- GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
- Citation
- PHARMAZIE, v.62, no.12, pp.937 - 942
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMAZIE
- Volume
- 62
- Number
- 12
- Start Page
- 937
- End Page
- 942
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/83461
- DOI
- 10.1691/ph.2007.12.7563
- ISSN
- 0031-7144
- Abstract
- Curcumin, the major yellow pigment in turmeric (Curcuma longa), is a well-documented naturally-occurring anti-oxidant with numerous pharmacological activities such as anti-inflammatory, anti-carcinogenic and anti-bacterial effects. In this study, curcumin's neuroprotective effect was carefully examined using a coculture system, based on reports that curcumin-containing plants are neuroprotective. Coculturing neuronal cells and activated microglial cells enhanced dopamine-induced neuronal cell death from 30% up to 50%. However, curcumin did not protect dopamine-directed neuronal cell death and sodium nitroprosside (SNP)-induced NO generation, but only blocked activated microglial cell-mediated neuronal cell damage under inflammatory conditions. Indeed, curcumin blocked the production of pro-inflammatory and cytotoxic mediators such as NO, TNF-alpha, IL-1 alpha, and IL-6 produced from A beta(25-35)/IFN-gamma-and LPS-stimulated microglia, in a dose-dependent manner. Therefore, our results suggest that curcumin-mediated neuroprotective effects may be mostly due to its anti-inflammatory effects.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.