Cytotoxic and DNA Topoisomerases I and II inhibitory constituents from the roots of Aralia cordata
- Authors
- Seo, CS[Seo, Chang-Seob]; Li, G[Li, Gao]; Kim, CH[Kim, Chull-Ho]; Lee, CS[Lee, Chong-Soon]; Jahng, Y[Jahng, Yurngdong]; Chang, HW[Chang, Hyun-Wook]; Son, JK[Son, Jong-Keun]
- Issue Date
- Nov-2007
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Aralia cordata; araliaceae; diterpene; DNA topoisomerases I and II inhibitor; cytotoxicity
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.30, no.11, pp.1404 - 1409
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 30
- Number
- 11
- Start Page
- 1404
- End Page
- 1409
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/83696
- DOI
- 10.1007/BF02977364
- ISSN
- 0253-6269
- Abstract
- Bioactivity-guided fractionation, based on the DNA topoisomerase inhibitory activity, lead to the isolation of five compounds (1-5) from the methylene chloride extract of the roots of Aralia cordata Thunb. (Araliaceae). These compounds were identified as ent-pimara-8(14),15-dien-19oic acid (1), ent-pimara-8(14),15-dien-18-oic acid (2), 16 alpha-hydrogen-17-isovaleryloxy-ent-kauran-19-oic acid (3), 16 alpha-hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (4) and dehydrofalcarindiol-8-acetate (5) from their spectral data. Compound 3 was isolated for the first time from this plant, and also showed the strongest inhibition of both DNA topoisomerase I and If activities, with 53 and 96% inhibitions, respectively, at a concentration of 20 mu M. However, all the compounds exhibited either weak or no cytotoxicities against the human colon carcinoma cell line (HT-29), the human breast carcinoma cell line (MCF-7) and human hepato blastoma cell line (HepG-2).
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Collections - Science > Department of Biological Science > 1. Journal Articles
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