Decreased hippocampal cholinergic neuro stimulating peptide precursor protein associated with stress exposure in rat brain by proteomic analysis
- Authors
- Kim, HG[Kim, Hong Gi]; Kim, KL[Kim, Kil Lyong]
- Issue Date
- Oct-2007
- Publisher
- WILEY-LISS
- Keywords
- stress exposure; rat brain; hippocampal cholinergic neurostimulating peptide precursor protein; proteomics
- Citation
- JOURNAL OF NEUROSCIENCE RESEARCH, v.85, no.13, pp.2898 - 2908
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEUROSCIENCE RESEARCH
- Volume
- 85
- Number
- 13
- Start Page
- 2898
- End Page
- 2908
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/83807
- DOI
- 10.1002/jnr.21407
- ISSN
- 0360-4012
- Abstract
- The stress response alters behavior, autonomic function, and secretion of multiple hormones, including corticotropin-releasing factor, adrenocorticotropin hormone, and cortisol, through the hypothalamic-pituitary-adrenal axis. Constitutive stress responses lead to a number of psychiatric disorders, including depression, posttraumatic stress disorder, Alzheimer's disease (AD), and other anxiety disorders through increased stress hormones and other unknown factors. Here, we performed a proteomic analysis of rat brain exposed to restraint stress compared with a nonstress group by using 2D-DIGE and MALDI-TOF analysis. Several proteins were identified by peptide mass fingerprint (PMF), including down-regulated hippocampal cholinergic neurostimulating peptide precursor protein (HCNP-pp). The current study demonstrates that HCNP-pp mRNA and protein expression are decreased in rat hippocampus after stress exposure. The level of HCNP-pp in H19-7, a rat hippocampal cell line, significantly decreases with dexamethasone treatment, a synthetic glucocorticoid. Thus, this finding suggests that HCNP-pp expression may decrease in response to stress exposure. Decreased HCNP-pp from stress exposure may result in lower levels of HCNP that might contribute to a loss of acetylcholine production. (c) 2007 Wiley-Liss, Inc.
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Collections - Science > Department of Biological Science > 1. Journal Articles
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