Vaccinations with dendritic cells primed with apoptotic tumor cells can elicit preventive antitumor immunity in a poorly immunogenic animal model of squamous cell carcinoma
- Authors
- Jeong, HS[Jeong, Han-Sin]; Lee, H[Lee, Hyunah]; Ko, Y[Ko, Yejeung]; Son, YI[Son, Young-Ik]
- Issue Date
- Sep-2007
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- dendritic cells; immunotherapy; squamous cell carcinoma; vaccines; animal models.
- Citation
- LARYNGOSCOPE, v.117, no.9, pp.1588 - 1593
- Indexed
- SCIE
SCOPUS
- Journal Title
- LARYNGOSCOPE
- Volume
- 117
- Number
- 9
- Start Page
- 1588
- End Page
- 1593
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/83923
- DOI
- 10.1097/M1LG.0b013e31806dd073
- ISSN
- 0023-852X
- Abstract
- Background: Dendritic cells (DCs) can effectively mediate the prevention and regression of a variety of solid tumors. However, not much has been determined about their efficacy for the prevention of squamous cell carcinoma (SCC), partly because there are no known tumor-specific antigens or low immunogenicity for this tumor. The authors aimed to determine the preventive effect of DC-based immunotherapy in a SCC animal model. Methods: Bone marrow derived DCs of C3H/He mice were pulsed with ultraviolet-B-irradiated apoptotic SCCVII cells, which are known as a poorly immunogenic SCC cell line. After the animals were vaccinated with these DCs, a tumorigenic dosage of SCCVII cells was subcutaneously injected and the tumor growth assessed. Results: Animals pretreated with apoptotic SCCVII cell-pulsed DCs showed tumor extinction within 2 weeks after forming a small tumor, or there was no tumor formation at all, as seen in 81% of the mice; in the remaining 19% of the mice, tumor growth was significantly retarded compared with the control groups (P =.0029). The SCCVII cell-specific T-cell response was observed in the immunized mice. Conclusion: The adoptive transfer of DCs primed with apoptotic tumor cells can hopefully serve as an effective preventive vaccine, even in poorly immunogenic SCC.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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