Detailed Information
Cited 22 time in 
Cited 28 time in 
Cited 28 time in
Metadata Downloads
Effects of vehicles and enhancers on transdermal delivery of clebopride
- Authors
- Rhee, YS[Rhee, Yun-Seok]; Huh, JY[Huh, Jai-Yong]; Park, CW[Park, Chun-Woong]; Nam, TY[Nam, Tae-Young]; Yoon, KR[Yoon, Koog-Ryul]; Chi, SC[Chi, Sang-Cheol]; Park, ES[Park, Eun-Seolk]
- Issue Date
- Sep-2007
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- clebopricle; skin permeation; vehicle; enhancer; binary vehicle system
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.30, no.9, pp.1155 - 1161
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 30
- Number
- 9
- Start Page
- 1155
- End Page
- 1161
- ISSN
- 0253-6269
- Abstract
- The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopricle. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopricle skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopricle, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 mu g/cm(2)/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.