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Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity
- Authors
- Park, C[Park, Chaehwa]; Lee, I[Lee, Inkyoung]; Jangc, JH[Jangc, Jun Ho]; Kang, WK[Kang, Won Ki]
- Issue Date
- 7-Aug-2007
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- RhoA; Erk; phosphatase; senescence
- Citation
- FEBS LETTERS, v.581, no.20, pp.3800 - 3804
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 581
- Number
- 20
- Start Page
- 3800
- End Page
- 3804
- ISSN
- 0014-5793
- Abstract
- Recently, negative effects of phosphatase in tumorigenesis and metastasis have been suggested in various tumor types. In this study, we showed that RhoA activation modulated phosphatase during senescence-like arrest in human prostate cancer cells. Under senescence-inducing condition, decreased Erk phosphorylation was detected in caRhoA-transfected cells and inactivation of Erk, but not p38, prevented doxorubicin-induced cell senescence. Cells were induced to senescence by inhibition of phosphatase activity (VHR, MKP3, or PP2A) without additional cellular stress. Of interest, caRhoA prevented doxorubicin-induced decrease of phosphatase. Thus, we postulate that RhoA signaling may protect cells against cellular senescence by maintaining phosphatase activity and Erk dephosphorylation. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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