Effect of positive bone marrow EBV in situ hybridization in staging and survival of localized extranodal natural killer/T-cell lymphorna, nasal-type
- Authors
- Lee, J[Lee, Jeeyun]; Suh, C[Suh, Cheolwon]; Huh, J[Huh, Jooryung]; Jun, HJ[Jun, Hyun Jung]; Kim, K[Kim, Kihyun]; Jung, C[Jung, Chulwon]; Park, K[Park, Keunchil]; Park, YH[Park, Yeon Hee]; Ko, YH[Ko, Young Hyeh]; Kim, WS[Kim, Won Seog]
- Issue Date
- 1-Jun-2007
- Publisher
- AMER ASSOC CANCER RESEARCH
- Citation
- CLINICAL CANCER RESEARCH, v.13, no.11, pp.3250 - 3254
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL CANCER RESEARCH
- Volume
- 13
- Number
- 11
- Start Page
- 3250
- End Page
- 3254
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/84329
- DOI
- 10.1158/1078-0432.CCR-06-2373
- ISSN
- 1078-0432
- Abstract
- Purpose: The aim of the study was to determine the effect of EBV-encoded RNA-1 in situ hybridization (EBER-1 ISH) in bone marrow specimens on survival outcome in patients with clinical stage I/II natural killer/T-cell lymphoma. Experimental Design: We systematically did EBER-1 ISH on 182 archival bone marrow tissues from 91 patients who were diagnosed of stage I/II natural killer/T-cell lymphoma and analyzed the correlation between bone marrow EBER-1 ISH status and survival. We defined minimal bone marrow involvement and definite bone marrow involvement to distinguish the subgroups who revealed EBV-positive cells from normal marrow by EBER-1 ISH from those who showed typical neoplastic cells in bone marrow biopsies. Results: In total, 17 of the 91 (18.7%) patients showed positivity for EBER-1 ISH at least in one of the bilateral bone marrow biopsies with 14 minimal bone marrow involvements and 3 definite bone marrow involvements. Patients with positive bone marrow EBER-1 ISH showed significantly poorer overall survival than those who were negative for bone marrow EBER-1 ISH (median survival, 16.1 months versus not reached; P = 0.045). Conclusion: Considering a high proportion of stage I/II patients (15.4%) with minimal in bone marrow specimens, bone marrow EBER-1 ISH should be routinely done in all patients with localized disease for more accurate staging.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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