Antidepressant-like effects of Albizzia julibrissin in mice: Involvement of the 5-HT1A receptor system
- Authors
- Kim, JH[Kim, Ji-Hyun]; Kim, SY[Kim, Sun Yeou]; Lee, SY[Lee, Seok-Yong]; Jang, CG[Jang, Choon-Gon]
- Issue Date
- May-2007
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Albizzia julibrissin; tail suspension; depression; mice; 5-HT receptor
- Citation
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, v.87, no.1, pp.41 - 47
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Volume
- 87
- Number
- 1
- Start Page
- 41
- End Page
- 47
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/84518
- DOI
- 10.1016/j.pbb.2007.03.018
- ISSN
- 0091-3057
- Abstract
- The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system. (c) 2007 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/84518)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.